The ublue releases (bazzite/bluefin/aurora) are tweaked to be set up and ready to go with minimal or no set up. You can switch between ublue and the normal fedora atomic distros, or even user customized variants, from what I understand. The root system will change, but anything installed under your user account will stay the same. The only problem that might occur between switching is that different desktop environments might overwrite some settings and cause problems that way. You would want a way to backup your config files just in case if you do a lot of switching.
This also means you can’t install multiple desktop environments side by side. Like if you wanted to choose between kde,gnome,xfce at the log in screen, it’s not possible under the atmoic distros. When i’ve done that on regular distros it would always result in a mess, and getting rid of a DE meant a lot of orphaned programs I didn’t want, so I avoid doing that, but this is a potential downside to the atomic distros. You would have to rebase and redownload stuff every time you switch DE.
Otherwise they are rock solid and basically designed to get you up and running as fast as possible, and be as stable as possible with seamless background updates. I’m running bluefin, and it’s the most user friendly and smooth experience on linux i’ve ever had.
Is it this issue? - https://github.com/ublue-os/bazzite/issues/2344